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Figure 7 | BMC Cancer

Figure 7

From: Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death

Figure 7

Synergistic cytotoxicity and anti-proliferative effects of Mito-ChM and 2-DG. (A) Representative pictures of the colonies formed. MCF-7 and MCF-10A cells were treated with 2-DG only (upper) or 2-DG in the presence of Mito-ChM (1 μM) (lower) for 4 h and the colonies formed were counted. (B) The survival fraction was calculated under the same conditions as in (A). (C,D) Cytotoxic effects of the combination of Mito-ChM and 2-DG. MCF-7 (main panels) and MCF-10A (inserts) cells were treated with 2-DG alone (at the indicated concentrations), 2-DG in the presence of 1 μM Mito-ChM (C) or 1 μM Mito-ChMAc (D) for 24 h and cell death was monitored in real time by Sytox Green staining. Data shown are the mean ± SEM. n = 4-6.

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