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Figure 6 | BMC Cancer

Figure 6

From: Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death

Figure 6

Tissue accumulation and tumor growth inhibitory activity of Mito-ChM in in vivo MDA-MB-231-luc xenograft model. (A) HPLC-MS/MS chromatograms (MRM transition: 679.1 → 515.0) of the Mito-ChM standard (1 μM), and of indicated tissue extracts from MDA-MB-231-luc tumor xenograft mice treated with Mito-ChM. Quantitative data on concentrations of Mito-ChM after normalization to tissue wet weight are shown in panel B. Tumor growth was determined by both bioluminescence signal intensity and tumor wet weight after 4 weeks of treatment. Representative bioluminescent images are show in (C). Quantitative data were plotted in panel D on bioluminescence signal intensity (left) and wet tumor weight (right). Data are represented as a percentage of control mice, mean ± SEM (n = 10, control group and n = 9, Mito-ChM treated group). *, P < 0.05 vs. control group.

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