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Table 4 Association between total alcohol and wine intake and ovarian borderline tumors, OCAC studies

From: Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium

Intake/d

Controls N=10,358

Serous borderline N=818

Mucinous borderline N=561

 

Total alcohol *

 

Ca

OR (95% CI)

Ca

OR (95% CI)

P value†

 None

4,296

297

1.0 (Ref)

181

1.0 (Ref)

 

 Up to 1 drink

3,928

349

0.87 (0.72-1.05)

245

0.95 (0.76-1.20)

 

 1-2 drinks

1,112

86

0.91 (0.69-1.20)

59

0.86 (0.62-1.20)

 

 2-3 drinks

400

32

1.04 (0.69-1.56)

23

0.94 (0.58-1.51)

 

 >3 drinks

622

54

1.19 (0.86-1.66)

53

1.40 (0.99-1.20)

 

P trend

  

0.45

 

0.22

0.39

 >2 drinks §

1,022

86

1.13 (0.86-1.49)

76

1.22 (0.90-1.66)

 

P trend §

  

0.63

 

0.42

0.67

Wine

      

 None

5,307

405

1.0 (Ref)

263

1.0 (Ref)

 

 Up to 4 oz

3,984

336

0.89 (0.74-1.06)

236

0.89 (0.72-1.10)

 

 4-8 oz

522

38

0.99 (0.68-1.43)

26

0.88 (0.57-1.36)

 

 >8 oz

545

39

0.99 (0.69-1.44)

36

1.03 (0.69-1.52)

 

P trend

  

0.66

 

0.72

0.87

 >4 oz §

1,067

77

0.99 (0.75-1.31)

62

0.96 (0.70-1.31)

 

P trend §

  

0.52

 

0.52

0.69

  1. Adjusted for age (<40; 40-49; 50-59; 60-69; 70+ years), smoking status (never, former, current), site (AUS, CON, DOV, GER, HAW, HOP, MAL, NCO, NEC, NJO, POL, SON), race/ethnicity (white nonHispanic; white Hispanic; black non Hispanic; Asian; other or unknown); menopausal status (pre/peri-menopausal; postmenopausal, unknown or missing), oral contraceptive use (<6mo, 6-22 mo, 23+ mo, unknown or missing), tubal ligation (yes; no; unknown or missing), endometriosis (yes; no; unknown or missing), hysterectomy (yes; no; unknown or missing), family history of breast or ovarian cancer in first-degree relatives (no; yes; unknown; no daughters or sisters), parity/age at last birth (nulliparous; 1-2 births/age ≤25 yrs at last pregnancy; 3+ births/age ≤25 yrs at last pregnancy; 1-2 births/age >25 years at last pregnancy; 3+ births/age >25 years at last pregnancy; yes if ever pregnant but unknown or missing age at last pregnancy age; no or unknown if ever pregnant and missing age at last pregnancy, interview year (1990-1994; 1995-1999; 2000-2004; 2005-2009; missing), age at menarche (8-10 yrs; 11 yrs; 12 yrs; 13 yrs; 14-21 yrs; <8 or ≥ 22 yrs), body mass index (continuous) and education (less than high school, high school, some college, completed college or university, completed graduate or professional degree, missing). Wine consumption was additionally adjusted for other alcoholic beverage types. Models include interaction terms between site and each covariate except alcohol.
  2. * 1 drink = 10 grams ethanol.
  3. † P for tumor heterogeneity derived from testing the trend variable for alcohol or wine intake in polytomous regression models with 2 df (see Statistical analysis).
  4. § Risk estimates and P trend values are from models that collapse the two highest intake categories.
  5. Models are also simultaneously adjusted for consumption of beer and liquor intake.
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BMC Cancer

ISSN: 1471-2407

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