Table 2 Discordant findings of histopathology and DR imaging results

5

Proliferative growth

Tumor epithelial cells were seen invading into the underlying connective tissue in the form of cords, islands, strands and nests. The invading cells exhibited features of pleomorphism, hyperchromasia, increased nuclear to cytoplasmic ratio and abnormal mitotic figures. Few keratin pearl formations were evident. Features suggestive of MDSCC.

Normal

12

Verrucous growth

Breach in the basement membrane was evident and tumor epithelial cells were seen invading into the underlying connective tissue in the form of islands, strands and nests. Keratin pearl formations were few. Tumor epithelial cells showed hyperchromasia, increased nuclear to cytoplasmic ratio, pleomorphism and abnormal mitotic figures. Features suggestive of MDSCC.

Normal

18

Non-specific ulcer

The epithelium was hyperchromatic in the basilar one-third region. Dense chronic inflammatory cells were seen within the connective tissue in the ulcerated region. Features suggestive of epithelial hyperplasia with mild dysplasia.

Normal

23

Non-healing ulcer

Epithelium exhibits no features of dysplasia. Moderate collections of chronic inflammatory cells were seen in the juxta epithelial region. Features suggestive of EHP with no dysplasia.

Pre-malignant

36

Ulcerated lesion with keratotic border

Epithelium exhibits features of hyperchromasia, increased mitotic figures, increased nuclear; cytoplasmic ratio, increased basilar hyperplasia involving two third of the epithelium. Chronic inflammatory cells were moderately dispersed in the juxta epithelial region. Features suggestive of EHP with moderate dysplasia.

Normal

39

Non-specific ulcer

Basal and suprabasal cells exhibited hyperplasia and hyperchromasia. The inflammatory cells were chronic and diffusely spread within the connective tissue. Features suggestive of EHP with mild dysplasia.

Normal