Table 3 List of genes differentially expressed between functional p53 and non functional p53 groups
From: Integral analysis of p53 and its value as prognostic factor in sporadic colon cancer
Gene name | Chr. position | Gene description | p-value , p53 functional vs., p53 non functional |
|---|---|---|---|
PRKCZ | 1p36.33-p36.2 | Serine threonine kinase involved in several processes such as proliferation, differentiation and secretion. | 4.95E-04 |
| Ā | Ā | Ā | ānon functional |
LMO3 | 12p12.3 | Lim domain only 3 (rhombotin like 2). Expression of LMO-3 represses p53 mediated mRNA expression of target genes. | 1.2E-02 |
ānon functional | |||
CDKN1A | 6p21.2 | Cyclin dependent kinase inhibitor. Causes cell cycle arrest in the presence of DNA damage. | 1.3E-02āfunctional |
PDE6A | 5q31.2-q34 | Phosphodiesterase 6A, cGMP-specific, rod, alpha | 7.47E-02 |
ānon functional | |||
SIAH1 | 16q12 | Seven in absentia homolog 1. Involved in ubiquitination and proteosome related degradation of specific proteins like beta catenin. | 2.60E-02 |
ānon functional | |||
TPD52L2 | 20q13.2-q13.3 | Tumor protein D52 like 2. Expressed in childhood leukemia and testes. | 4.65E-02 |
ānon functional | |||
MDM2 | 12q14.3-q15 | MDM2 p53 binding protein homolog (Mouse) | 1.25E-02 |
ā functional | |||
HMGCS1 | 5p14-p13 | 3-hydroxy 3-methylglutaryl-CoA synthase I | 1E-01 |
āfunctional |