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Table 3 List of genes differentially expressed between functional p53 and non functional p53 groups

From: Integral analysis of p53 and its value as prognostic factor in sporadic colon cancer

Gene name Chr. position Gene description p-value , p53 functional vs., p53 non functional
PRKCZ 1p36.33-p36.2 Serine threonine kinase involved in several processes such as proliferation, differentiation and secretion. 4.95E-04
    ↑non functional
LMO3 12p12.3 Lim domain only 3 (rhombotin like 2). Expression of LMO-3 represses p53 mediated mRNA expression of target genes. 1.2E-02
↑non functional
CDKN1A 6p21.2 Cyclin dependent kinase inhibitor. Causes cell cycle arrest in the presence of DNA damage. 1.3E-02↑functional
PDE6A 5q31.2-q34 Phosphodiesterase 6A, cGMP-specific, rod, alpha 7.47E-02
↑non functional
SIAH1 16q12 Seven in absentia homolog 1. Involved in ubiquitination and proteosome related degradation of specific proteins like beta catenin. 2.60E-02
↑non functional
TPD52L2 20q13.2-q13.3 Tumor protein D52 like 2. Expressed in childhood leukemia and testes. 4.65E-02
↑non functional
MDM2 12q14.3-q15 MDM2 p53 binding protein homolog (Mouse) 1.25E-02
↑ functional
HMGCS1 5p14-p13 3-hydroxy 3-methylglutaryl-CoA synthase I 1E-01
  1. All p-values are corrected for multiple tests.