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Table 2 Associations between clinicopathological variables and p53 functionality

From: Integral analysis of p53 and its value as prognostic factor in sporadic colon cancer

Ā 

p53 non functional N (%)

p53 functional N (%)

p value

TP53 mutational status

Ā Ā Ā 

wt

7 (33)

14 (78)

0.01

mut

14 (67)

4 (22)

Ā 

P53 IHC

Ā Ā Ā 

0

3 (11)

7 (24)

<0.001#

0 - ā‰¤25%

1 (3)

22 (76)

Ā 

>25%

24 (86)

0 (0)

Ā 

Chr. 17 p status

Ā Ā Ā 

AB

5 (18)

22 (76)

<0.001*

LOH

2 (7)

4 (14)

Ā 

Copy neutral LOH

9 (32)

0 (0)

Amplified LOH

5 (18)

1 (3)

Allelic Imbalance

1(4)

0 (0)

Two clones

6 (21)

2 (7)

Age category

Ā Ā Ā 

50 ā€“ 59

4 (14)

6 (22)

NS

60 ā€“ 69

10 (36)

9 (32)

Ā 

70 ā€“ 79

10 (36)

9 (32)

Ā 

80 ā€“ 89

4 (14)

4 (14)

Ā 

DNA index

Ā Ā Ā 

0.95 ā€“ 1.05

6 (22)

21 (78)

<0.001Ā¶

1.06 ā€“ 1.4

4 (15)

3 (11)

Ā 

1.41 ā€“ 1.95

17 (63)

3 (11)

Ā 

MMR status

Ā Ā Ā 

MSI

4 (14)

14 (50)

0.009

MSS

24 (86)

14 (50)

Ā 

Gender

Ā Ā Ā 

Male

12 (43)

18 (62)

NS

Female

16 (57)

11 (38)

Ā 

Tumor Location

Ā Ā Ā 

Right

10 (36)

19 (66)

0.035

Left

18 (64)

10 (34)

Ā 

Stage

Ā Ā Ā 

I and II

14 (50)

22 (76)

0.06

III

14 (50)

7 (24)

Ā 

Median Follow up in months

66.75

89.77

0.4

  1. *Ī§2 test allelic status AB vs. LOH p=0.58; AB vs. CNLOH p<0.001; AB vs. ALOH p=0.005; AB vs. two clones p=0.006
  2. LOH vs. CNLOH p=0.01; LOH vs. ALOH p=0.24; LOH vs. two clones p=0.28.
  3. ALOH vs. CNLOH p=0.43; Amp LOH vs. two clones p=1.
  4. CNLOH vs. two clones p=0.48.
  5. # Ī§2 test p53 IHC 0 vs. 0-25% p=0.07; 0 vs. >25% p<0.001; 0-25% vs. >25% p=0.001.
  6. Ā¶ Ī§2 test DNA index 0.95 ā€“ 1.05 vs. 1.06 ā€“ 1.4 p=0.16; 0.95 ā€“ 1.05 vs. 1.41- 1.95 p<0.001; 1.06 ā€“ 1.40 vs. 1.41 ā€“ 1.95 p=0.29.