From: Integral analysis of p53 and its value as prognostic factor in sporadic colon cancer
Ā | p53 non functional N (%) | p53 functional N (%) | p value |
---|---|---|---|
TP53 mutational status | Ā | Ā | Ā |
wt | 7 (33) | 14 (78) | 0.01 |
mut | 14 (67) | 4 (22) | Ā |
P53 IHC | Ā | Ā | Ā |
0 | 3 (11) | 7 (24) | <0.001# |
0 - ā¤25% | 1 (3) | 22 (76) | Ā |
>25% | 24 (86) | 0 (0) | Ā |
Chr. 17 p status | Ā | Ā | Ā |
AB | 5 (18) | 22 (76) | <0.001* |
LOH | 2 (7) | 4 (14) | Ā |
Copy neutral LOH | 9 (32) | 0 (0) | |
Amplified LOH | 5 (18) | 1 (3) | |
Allelic Imbalance | 1(4) | 0 (0) | |
Two clones | 6 (21) | 2 (7) | |
Age category | Ā | Ā | Ā |
50 ā 59 | 4 (14) | 6 (22) | NS |
60 ā 69 | 10 (36) | 9 (32) | Ā |
70 ā 79 | 10 (36) | 9 (32) | Ā |
80 ā 89 | 4 (14) | 4 (14) | Ā |
DNA index | Ā | Ā | Ā |
0.95 ā 1.05 | 6 (22) | 21 (78) | <0.001Ā¶ |
1.06 ā 1.4 | 4 (15) | 3 (11) | Ā |
1.41 ā 1.95 | 17 (63) | 3 (11) | Ā |
MMR status | Ā | Ā | Ā |
MSI | 4 (14) | 14 (50) | 0.009 |
MSS | 24 (86) | 14 (50) | Ā |
Gender | Ā | Ā | Ā |
Male | 12 (43) | 18 (62) | NS |
Female | 16 (57) | 11 (38) | Ā |
Tumor Location | Ā | Ā | Ā |
Right | 10 (36) | 19 (66) | 0.035 |
Left | 18 (64) | 10 (34) | Ā |
Stage | Ā | Ā | Ā |
I and II | 14 (50) | 22 (76) | 0.06 |
III | 14 (50) | 7 (24) | Ā |
Median Follow up in months | 66.75 | 89.77 | 0.4 |