Diagnostic markers of urothelial cancer based on DNA methylation analysis

BMC Cancer

Table 1 Clinical characteristics of UC and control patients

	Training set	Tissue validation set	Urine validation set
Control patients (n = 51)	12 (N)	21 (N)	18 (NU)
Age, median (range) (years)	63 (50–80)	62 (27–82)	54 (16–77)
Male/female	12/0	13/8	6/12
UC patients (n = 217)	91 (T)	53 (T)	73 (TU)
Age, median (range) (years)	66 (40–91)	69 (49–85)	69 (36–88)
Male/female	80/11	42/11	59/14
Tumor-adjacent normal tissue ^*	34 (CN)	25 (CN)	-
Tumor Stage in UC patients
Ta	20	2	7
T1	32	16	30
T2	13	9	24
T3	20	21	10
T4	6	5	2
Tumor Grade in UC patients
G1	5	0	5
G2	38	25	32
G3	48	28	36

*Samples of normal-appearing tissue adjacent to the tumor were collected from UC patients for each set. Abbreviations: N normal urothelial tissue, CN corresponding normal-appearing tissue adjacent to the tumor in UC patients, T tumor tissue, NU urine sediments from healthy volunteers, TU urine sediments from UC patients.
Urothelial tissue samples were collected during surgical procedures from UC and control patients. Urine samples were collected from UC patients and healthy volunteers. Samples were divided into experimental groups as given.

ISSN: 1471-2407