Table 1 Inclusion and exclusion criteria

• Patients with advanced prostate cancer receiving Antiandrogen therapy for at least 4 weeks or

• Anemia > 8 g/dl

• Platelet count ≤ 10000/μl

• COPD

• Patients with advanced prostate cancer receiving Antiandrogen therapy in combination with chemotherapy (baseline test before chemotherapy)

• CNS Metastasis

• Epilepsy

• Planned Surgery

• Heart failure (NYHA III-IV)

• Hemoglobin > 9 g/dl

• Coronary disease

• Ejection fraction ≥ 60%

• Therapy refractory Hypertension

• Forced expiratory volume in one second ≥ 50%

• Other internistic diseases that rule out exercise

• Orthopedic handicaps that rule out exercise

• Age ≥ 18 years

• Psychological problems which are critical in view of the responsible medical doctor

• Expectation of life ≥ 6 month

• Written consent

• Inconspicuous ultrasound of the patients heart

• Inconspicuous ECG (rest and stress)