Claudin 1 expression in basal-like breast cancer is related to patient age

BMC Cancer

Table 2 Claudin 1 but not claudin 4 expression in basal-like breast tumors was significantly associated with patient age

Clinical parameters	Subgroup cutoffs	Claudin 1				Claudin 4
Clinical parameters	Subgroup cutoffs	High H-score >40	Low H-score ≤40	n	pvalue¹	High H-score >25	Low H-score ≤25	n	pvalue¹
Node	+ve	18	13	31	0.21	15	14	29	0.64
	-ve	17	25	42		23	15	38
Age	>55	23	14	37	0.034 *	20	13	33	0.81
	≤55	15	27	42		22	18	40
Grade	low (3–5)	3	0	3	0.92	3	0	3	0.45
	moderate (6–7)	25	33	58		27	27	54
	high (8–9)	10	8	18		12	4	16
Size	>2cm	27	31	58	1	32	23	55	1
	≤2cm	8	10	18		9	7	16

Breast tumors derived from women >55 years of age, had the highest claudin 1 levels. Expression was not significantly associated with other parameters examined.
¹Continuity adjusted Chi-Square was used for node, age and size data, Exact Linear Association was used for grade. * Statistically significant, p<0.05.

ISSN: 1471-2407