Figure 5

Methylation volatility. Legend: A) Each row represents the sequenced CpG sites of one gene with each bar standing for one CpG-site in 5′ to 3′ direction. Bar height denotes the average methylation-score of that CpG-site across all cell lines. Variably methylated genes (AKAP12, BRMS1, TIMP3, KiSS-1) showed generally higher methylation with greater volatility than genes with constant methylation (CDH1, SERPINB5). B) The observation in A is quantified by differing levels of methylation volatility: genes with constant methylation had lower standard deviation of methylation levels than those with variable methylation.