Table 3 Worse toxicity events by grade and treatment dose group- N of patients

Hemoglobin

17

2

1

.

16

3

1

.

14

2

.

.

ND

Leukocytes

5

.

1

2

2

3

1

2

3

3

2

1

ND

Neutrophils

1

1

2

1

5

1

1

2

3

1

2

2

ND

Platelets

4

.

.

.

1

.

.

.

1

.

.

.

ND

Neuropathy Sensor

1

1

.

.

2

.

.

.

3

.

.

.

ND

Diarrhea

2

.

.

.

1

.

1

.

.

.

.

.

ND

Constipation

2

.

.

.

2

.

.

.

1

.

1

.

ND

Fatigue

7

.

.

.

5

.

1

.

4

.

.

1

ND

Metabolic/Laboratory

6

1

1

.

3

2

1

.

5

1

.

.

ND

Pain

1

2

2

.

6

.

.

.

2

1

.

.

ND

Hemoptysis

.

1

.

.

1

.

.

.

.

.

.

.

ND

Edema: limb

.

.

.

.

1

.

1

.

1

.

1

.

ND

Upper Respiratory

3

.

2

.

3

.

.

.

.

.

.

.

ND

Febrile Neutropenia

.

.

.

.

.

.

1

.

.

.

.

.

ND

Gastrointestinal

1

.

.

.

6

2

.

.

1

.

.

0,035

Weight (Gain- Loss)

.

2

1

.

1

.

.

.

.

.

.

.

ND

Fever

.

1

.

.

1

.

.

.

1

1

.

.

ND

Lymphopenia

.

3

.

.

2

1

1

.

.

.

.

.

0,032