Skip to main content

Table 3 Worse toxicity events by grade and treatment dose group- N of patients

From: Dose selection trial of metronomic oral vinorelbine monotherapy in patients with metastatic cancer: a hellenic cooperative oncology group clinical translational study

Label of variable Treatment dose group FISH test p value
Vinorelbine 30mg Vinorelbine 40mg Vinorelbine 50mg  
Grade Grade Grade  
1 2 3 4 1 2 3 4 1 2 3 4  
Hemoglobin 17 2 1 . 16 3 1 . 14 2 . . ND
Leukocytes 5 . 1 2 2 3 1 2 3 3 2 1 ND
Neutrophils 1 1 2 1 5 1 1 2 3 1 2 2 ND
Platelets 4 . . . 1 . . . 1 . . . ND
Neuropathy Sensor 1 1 . . 2 . . . 3 . . . ND
Diarrhea 2 . . . 1 . 1 . . . . . ND
Constipation 2 . . . 2 . . . 1 . 1 . ND
Fatigue 7 . . . 5 . 1 . 4 . . 1 ND
Metabolic/Laboratory 6 1 1 . 3 2 1 . 5 1 . . ND
Pain 1 2 2 . 6 . . . 2 1 . . ND
Hemoptysis . 1 . . 1 . . . . . . . ND
Edema: limb . . . . 1 . 1 . 1 . 1 . ND
Upper Respiratory 3 . 2 . 3 . . . . . . . ND
Febrile Neutropenia . . . . . . 1 . . . . . ND
Gastrointestinal 1 . . . 6 2 . .   1 . . 0,035
Weight (Gain- Loss) . 2 1 . 1 . . . . . . . ND
Fever . 1 . . 1 . . . 1 1 . . ND
Lymphopenia . 3 . . 2 1 1 . . . . . 0,032