p16 Negative | p16 Positive | ||||
---|---|---|---|---|---|
Patient/Tumour Data | No. | % | No. | % | p |
Nº of patients | 90 | 18 | |||
Age, years | |||||
Median | 59 | 57 | NS | ||
Range | 33-84 | 44-77 | |||
Sex | |||||
Male | 84 | 93 | 17 | 94 | NS |
Female | 6 | 7 | 1 | 6 | |
Current smokers | |||||
No | 3 | 3 | 3 | 16 | |
Yes | 67 | 74 | 10 | 55 | 0.01 |
Unknown | 20 | 23 | 5 | 29 | |
Alcohol consumption | |||||
No | 10 | 11 | 3 | 16 | |
Yes | 57 | 63 | 10 | 55 | NS |
Unknown | 23 | 26 | 5 | 29 | |
Performance status | |||||
ECOG 0 | 36 | 40 | 9 | 50 | NS |
ECOG 1 | 43 | 48 | 8 | 44 | |
ECOG 2 | 11 | 12 | 1 | 6 | |
Tumor site | |||||
Oral cavity | 14 | 16 | 2 | 11 | 0.04 |
Oropharynx | 30 | 33 | 9 | 50 | |
Larynx | 36 | 40 | 2 | 11 | |
Hypopharynx | 10 | 11 | 5 | 28 | |
PCR - HPV status | |||||
HR-HPV (16,18,51,58) | 8 | 9 | 9 | 50 | |
LR-HPV (5,6) | 2 | 2 | 1 | 5.5 | 0.0001 |
Unknown subtype | 1 | 1 | 1 | 5.5 | |
Negative | 79 | 88 | 7 | 39 | |
Grade | |||||
Well/Moderate | 40 | 44 | 6 | 33 | NS |
Poor | 9 | 10 | 2 | 11 | |
Unknown | 41 | 46 | 10 | 56 | |
Tumour stage | |||||
T1-T3 | 37 | 41 | 5 | 28 | NS |
T4 | 53 | 59 | 13 | 72 | |
Nodal status | |||||
No | 28 | 31 | 5 | 28 | NS |
N+ | 62 | 69 | 13 | 72 | |
Stage | |||||
III | 28 | 31 | 6 | 33 | NS |
IV | 62 | 59 | 12 | 67 | |
Treatment | |||||
RT-CT | 46 | 51 | 10 | 56 | NS |
RT-EGFR inhibitors | 44 | 49 | 8 | 44 | |
Irradiation dose | |||||
Mean | 71 | 71.4 | NS | ||
Range | 57-78 | 70-74 | |||
Type of radiotherapy | |||||
Conventional RT | 11 | 12 | 0 | 0 | NS |
Concomitant boost | 79 | 88 | 18 | 100 | |
Response | |||||
Complete response | 67 | 74 | 16 | 89 | |
Partial response | 16 | 18 | 0 | 0 | NS |
Stable disease | 1 | 1 | 1 | 5.5 | |
Progression | 0 | 0 | 1 | 5.5 | |
Unknown | 6 | 7 | 0 | 0 | |
Median OS (months) | 32 | 54 | NS | ||
Range | 14-50 | 20-87 | |||
Median DFS (months) | 18 | 52 | NS | ||
Range | 13-24 | 0-103 |