Figure 4From: Destructive impact of t-lymphocytes, NK and mast cells on basal cell layers: implications for tumor invasion Lymphocyte infiltration at sites of focal capsule disruptions of in situ cancer tissues. Paraffin-embedded human breast (A-B) and prostate (C-D) tissue sections were double immunostained for SMA (red) plus LCA (brown) or CK34βE12 plus LCA. Note that most infiltrating lymphocytes (arrows) are located on the site of focally disrupted epithelial capsules (circles), in which the overlying tumor cells formed tongue-like structures invading the adjacent stroma. A and C: 100X. B and D: a higher (400X) magnification of A and C, respectively.Back to article page