Drug | FISH | FACS | Rate of HAC loss |
---|---|---|---|
 | % Cells with HAC | % Cells with EGFP | per cell division** |
No drug | 86 (100)* | 85.1 ± 0.9 | 13 × 10-3 |
Taxol | 59 (139) | 59.5 ± 0.9 | 597 × 10-3 |
Ixabepilone | 71 (116) | 68.0 ± 0.1 | 396 × 10-3 |
Docetaxel | 74 (101) | 79.1 ± 1.8 | 133 × 10-3 |
Peloruside A | 68 (71) | 67.4 ± 0.9 | 411 × 10-3 |
Nocodazole | 79 (77) | 80.3 ± 0.9 | 107 × 10-3 |
SAHA | 79 (160) | 84.3 ± 1.2 | 12 × 10-3 |
VP16 (Etoposide) | 86 (156) | 80.7 ± 0.9 | 96 × 10-3 |
Reversine*** | 77 (71) | 79.0 ± 0.5 | 176 × 10-3 |
ZM-447439*** | 75 (75) | 70.4 ± 0.5 | 374 × 10-3 |