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Table 2 Micronuclei (MNi) formation in the HAC-containing HT1080 cells treated by different drugs

From: A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells

Drug Fraction of cells with MNi Mean ± SD (%)**
  Exp. 1 Exp. 2  
Vehicle* 3% 1% 2 ± 1
10 nM Taxol 43% 37% 40 ± 3
100 nM Peloruside A 74% 63% 69 ± 5
1 μM ZM447439 56% 57% 57 ± 1
100 nM Nocodazole 50% 56% 53 ± 3
  1. *Vehicle: 0.01% DMSO (this was the highest amount of DMSO used).
  2. ** Number of MN is given as means ± SD in two independent experiments.