Table 1 Drugs used in this study
Drug | Target | Concentration/ time treatment | Fold increase of HAC loss per cell division |
|---|---|---|---|
Microtubule-stabilizing drugs | |||
Taxol | Beta-tubulin | 10 nM-overnight | x 47 |
Ixabepilone | Beta-tubulin | 100 nM-overnight | x 31 |
Docetaxel | Beta-tubulin | 10 nM-2 hrs | x 10 |
Peloruside A | Beta-tubulin | 100 nM-overnight | x 32 |
Microtubule-depolymerizing drugs | |||
Nocodazole | Beta-tubulin | 1 μM-overnight | x 8 |
Other drugs | |||
SAHA | HDAC | 5 μM-overnight | x 1 |
VP16 (etoposide) | TOP2 | 8 μM-2hrs | x 7 |
Reversine | Aurora B, MPS1 | 1 μM-3 days | x 14 |
ZM-447439 | Aurora B | 1 μM-3 days | x 29 |