Figure 2

Tumor formation and growth of 4 tumor cells in nude mice. After normal human epidermal melanoma cells (HEM), human dermal melanoma cells (A375-WT), G6PD-deficient A375 cells (A375-G6PD∆), A375-G6PD∆ cells with overexpression of normal G6PD cDNA (A375-G6PD∆-G6PD-WT) and A375-G6PD∆ cells with overexpression of mutant G6PD cDNA (A375-G6PD∆-G6PD-G487A) were injected into the nude mice. The tumor size was measured on days 7, 12, 16, 19, 21 and 23 post-injection, and the tumor volume growth curve (A) was plotted. The nude mice were photographed on day 23 (B), and then sacrificed. The tumors were isolated, and the weights (C) and volume of the tumors were measured (D).