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Table 2 Labeling index (LI) in relation to grades of CIN and stages of invasive cervical carcinoma

From: Nuclear TK1 expression is an independent prognostic factor for survival in pre-malignant and malignant lesions of the cervix

Type

Grade/stage

No

TK1 total*

P

TK1 cyto + nucl**

P

Ki-67

P

CIN

Grade I

78

17.5±16.7

 

7.3±11.2

 

10.8±13.0

 
    

<0.0001

 

<0.0001

 

<0.0001

 

Grade II

64

37.2±22.9

 

22.1±18.7

 

26.5±21.2

 
    

<0.0001

 

<0.0001

 

<0.0001

Carcinoma in situ

Grade III

74

54.6±20.5

 

36.6±18.9

 

43.9±23.1

 

(CIN III)

    

0.001

 

0.041

 

<0.0001

Invasive CA

Stage II

50

66.6±17.8

 

43.5±18.4

 

60.5±23.1

 
    

0.029

 

0.117

 

0.701

 

Stage III

34

74.9±15.4

 

49.7±18.4

 

62.5±23.2

 
  1. *TK1 expression in cytoplasm alone + TK1 expression in both cytoplasm and nuclear; ** TK1 expression in cytoplasm + nuclear; No = number of patients. CA = carcinoma.