Table 4 Comparison of adverse events
Adverse event | DE + rh-endostatin (n = 35) | DE (n = 33) | ||
|---|---|---|---|---|
Grade 1-4 | Grade 3-4 | Grade 1-4 | Grade 3-4 | |
n (%) | n (%) | n (%) | n (%) | |
Anemia | 9 (25.7) | 1 (2.9) | 8 (24.2) | 2 (6.1) |
Leukopenia | 18 (51.4) | 7 (20.0) | 17 (51.5) | 9 (27.3) |
Neutropenia | 19 (54.3) | 7 (20.0) | 16 (48.5) | 8 (24.2) |
Thrombocytopenia | 3 (8.6) | 0 (0) | 4 (12.1) | 0 (0) |
Bilirubin elevation | 4 (11.4) | 1 (2.9) | 1 (3.0) | 0 (0) |
Transaminase elevation | 1 (2.9) | 0 (0) | 2 (6.1) | 0 (0) |
Stomatitis | 0 (0) | 0 (0) | 2 (6.1) | 0 (0) |
Nausea/vomiting | 20 (57.1) | 10 (28.6) | 23 (69.7) | 13 (39.4) |
Diarrhea | 1 (2.9) | 0 (0) | 0 (0) | 0 (0) |
Astriction | 0 (0) | 0 (0) | 1 (3.0) | 0 (0) |
Proteinuria | 3 (8.6) | 0 (0) | 1 (3.0) | 0 (0) |
Alopecia | 23 (65.7) | 22 (66.7) | ||
Arhythmia | 2 (5.7) | 0 (0) | 2 (6.1) | 0 (0) |
Cardiovascular dysfunction | 3 (8.6) | 0 (0) | 2 (6.1) | 0 (0) |
Peripheral neuropathy | 2 (5.7) | 0 (0) | 1 (3.0) | 0 (0) |
Hand-foot syndrome | 4 (11.4) | 3 (8.6) | 5 (15.2) | 1 (3.0) |
Fatigue | 26 (74.3) | 1 (2.9) | 25 (75.8) | 2 (6.1) |