Table 1 Correlation among Cygb, VEGF, PI3K, p-Akt, IL-6,TNFα expression and clinicopathological parameters of patients with gliomas
Vareable | Age (n = 88) | Gender | Histological grade | Recurrence | |||||
|---|---|---|---|---|---|---|---|---|---|
Male (n = 51) | Female (n = 37) | Grade I (n = 10) | Grade II (n = 37) | Grade III (n = 26) | Grade IV (n = 15) | No (n = 31) | Yes (n = 57) | ||
Cygb expression | |||||||||
Median | 39% | 30% | 52% | 56.5% | 66% | 31.5% | 14% | 64% | 22% |
Range | 10%-86% | 11%-85% | 10%-86% | 20%-86% | 12%-85% | 18%-52% | 10%-20% | 25%-86% | 10%-85% |
p value | 0.439▴ (r = -0.083) | 0.031△ | <0.01♦ | <0.01△ | |||||
PI3K expression | |||||||||
Median | 20% | 30% | 15% | 13% | 11% | 32.5% | 38% | 12% | 27% |
Range | 3%-62% | 3%-62% | 3%-60% | 3%-37% | 3%-58% | 7%-60% | 24%-62% | 3%-56% | 5%-62% |
p value | 0.236▴ (r = 0.128) | 0.055△ | <0.01♦ | <0.01△ | |||||
p-Akt expression | |||||||||
Median | 21% | 27% | 17% | 15% | 14% | 31.5% | 40% | 15% | 29% |
Range | 5%-67% | 5%-62% | 5%-67% | 5%-38% | 5%-60% | 10%-57% | 27%-67% | 5%-58% | 7%-67% |
p value | 0.135▴ (r = 0.161) | 0.091△ | <0.01♦ | <0.01△ | |||||
IL-6 expression | |||||||||
Median | 35% | 35% | 35% | 22.5% | 27% | 30% | 46% | 25% | 40% |
Range | 4%-70% | 5%-70% | 4%-68% | 4%-50% | 7%-68% | 8%-70% | 12%-66% | 4%-68% | 5%-70% |
p value | 0.859▴ (r = 0.019) | 0.472△ | 0.019♦ | 0.041△ | |||||
TNFα expression | |||||||||
Median | 30% | 27% | 33% | 16% | 22% | 33% | 47% | 21% | 35% |
Range | 3%-67% | 3%-67% | 4%-67% | 4%-46% | 3%-62% | 3%-67% | 10%-62% | 3%-62% | 3%-67% |
p value | 0.857▴ (r = -0.019) | 0.543△ | 0.010♦ | 0.123△ | |||||
VEGF expression | |||||||||
Median | 56% | 55% | 58% | 44% | 32% | 60.5% | 67% | 30% | 61% |
Range | 10%-89% | 10%-87% | 11%-89% | 11%-78% | 10%-85% | 10%-87% | 12%-89% | 10%-85% | 10%-89% |
p value | 0.178▴ (r = 0.145) | 0.337△ | 0.027♦ | 0.061△ | |||||