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Table 1 Correlation among Cygb, VEGF, PI3K, p-Akt, IL-6,TNFα expression and clinicopathological parameters of patients with gliomas

From: The expression of cytoglobin as a prognostic factor in gliomas: a retrospective analysis of 88 patients

Vareable Age (n = 88) Gender Histological grade Recurrence
   Male (n = 51) Female (n = 37) Grade I (n = 10) Grade II (n = 37) Grade III (n = 26) Grade IV (n = 15) No (n = 31) Yes (n = 57)
Cygb expression          
Median 39% 30% 52% 56.5% 66% 31.5% 14% 64% 22%
Range 10%-86% 11%-85% 10%-86% 20%-86% 12%-85% 18%-52% 10%-20% 25%-86% 10%-85%
p value 0.439 (r = -0.083) 0.031   <0.01     <0.01  
PI3K expression          
Median 20% 30% 15% 13% 11% 32.5% 38% 12% 27%
Range 3%-62% 3%-62% 3%-60% 3%-37% 3%-58% 7%-60% 24%-62% 3%-56% 5%-62%
p value 0.236 (r = 0.128) 0.055   <0.01     <0.01  
p-Akt expression          
Median 21% 27% 17% 15% 14% 31.5% 40% 15% 29%
Range 5%-67% 5%-62% 5%-67% 5%-38% 5%-60% 10%-57% 27%-67% 5%-58% 7%-67%
p value 0.135 (r = 0.161) 0.091   <0.01     <0.01  
IL-6 expression          
Median 35% 35% 35% 22.5% 27% 30% 46% 25% 40%
Range 4%-70% 5%-70% 4%-68% 4%-50% 7%-68% 8%-70% 12%-66% 4%-68% 5%-70%
p value 0.859 (r = 0.019) 0.472   0.019     0.041  
TNFα expression          
Median 30% 27% 33% 16% 22% 33% 47% 21% 35%
Range 3%-67% 3%-67% 4%-67% 4%-46% 3%-62% 3%-67% 10%-62% 3%-62% 3%-67%
p value 0.857 (r = -0.019) 0.543   0.010     0.123  
VEGF expression          
Median 56% 55% 58% 44% 32% 60.5% 67% 30% 61%
Range 10%-89% 10%-87% 11%-89% 11%-78% 10%-85% 10%-87% 12%-89% 10%-85% 10%-89%
p value 0.178 (r = 0.145) 0.337   0.027     0.061  
  1. Results Spearman’s correlation coefficient. Results Mann–Whitney U test. ♦ Results Kruskal–Wallis ANOVA.