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Table 1 Globaltest results

From: IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma

KEGG pathway Analysis adj P Statistic Expected Std.dev
Insulin signaling pathway OScellvsOB 1.01∙10-7 26.34 4.76 1.92
  OScellvsMSC 3.07∙10-15 35.12 3.33 1.78
Oocyte meiosis OScellvsOB 2.70∙10-7 37.45 4.76 2.9
  OScellvsMSC 5.04∙10-16 53.7 3.33 2.84
Ubiquitin mediated proteolysis OScellvsOB 3.21∙10-7 22.88 4.76 1.75
  OScellvsMSC 5.04∙10-16 37.99 3.33 1.89
Progesterone-mediated oocyte maturation OScellvsOB 7.16∙10-7 34.26 4.76 2.71
  OScellvsMSC 1.34∙10-15 55.35 3.33 2.77
Glycerophospholipid metabolism OScellvsOB 1.40∙10-6 27.13 4.76 2.25
  OScellvsMSC 2.25∙10-15 55.86 3.33 2.82
  1. The top five significant pathways with aberrant expression in both osteosarcoma cell lines versus osteoblasts (OScellvsOB) and osteosarcoma cell lines versus mesenchymal stem cells (OScellvsMSC). adjP: FDR-adjusted p-value, Statistic: test statistic of the globaltest, Expected: expected test statistic of the globaltest, Std.dev: standard deviation under the null hypothesis.