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Table 1 Globaltest results

From: IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma

KEGG pathway

Analysis

adj P

Statistic

Expected

Std.dev

Insulin signaling pathway

OScellvsOB

1.01∙10-7

26.34

4.76

1.92

 

OScellvsMSC

3.07∙10-15

35.12

3.33

1.78

Oocyte meiosis

OScellvsOB

2.70∙10-7

37.45

4.76

2.9

 

OScellvsMSC

5.04∙10-16

53.7

3.33

2.84

Ubiquitin mediated proteolysis

OScellvsOB

3.21∙10-7

22.88

4.76

1.75

 

OScellvsMSC

5.04∙10-16

37.99

3.33

1.89

Progesterone-mediated oocyte maturation

OScellvsOB

7.16∙10-7

34.26

4.76

2.71

 

OScellvsMSC

1.34∙10-15

55.35

3.33

2.77

Glycerophospholipid metabolism

OScellvsOB

1.40∙10-6

27.13

4.76

2.25

 

OScellvsMSC

2.25∙10-15

55.86

3.33

2.82

  1. The top five significant pathways with aberrant expression in both osteosarcoma cell lines versus osteoblasts (OScellvsOB) and osteosarcoma cell lines versus mesenchymal stem cells (OScellvsMSC). adjP: FDR-adjusted p-value, Statistic: test statistic of the globaltest, Expected: expected test statistic of the globaltest, Std.dev: standard deviation under the null hypothesis.