Figure 4From: IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma Inhibition of osteosarcoma cell lines with OSI-906. Osteosarcoma cell lines were inhibited with different concentrations of OSI-906, for 72 (gray line) or 96 (black line) hours. OHS (A), KPD (B), and SAOS2 (C) showed a dose-dependent inhibition, while 143B (D) did not respond to OSI-906.Back to article page