Figure 3From: IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma Validation of IR/IGF1R downstream signaling. Western blot of IRS-1 and p-IRS-1 of lysates of untreated (−) osteosarcoma cell lines OHS, KPD, SAOS2, and 143B, and of these cells treated for 3 hrs with 1 μM of OSI-906 (+).Back to article page