Figure 2
From: IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma
Ingenuity pathways analysis canonical pathway IGF1 signaling This figure shows the IGF1 signaling pathway, with significantly upregulated genes in red, downregulated genes in green, and genes that did not meet our criteria for significance in gray. The left part of the symbols shows the analysis of osteosarcoma cell lines as compared with mesenchymal stem cells, the right part as compared with osteoblasts. Most consensus in gene expression is found upstream IGF1R signaling, in the expression of the IGF binding proteins.