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Table 5 Clinic pathological characteristics of tumors from individuals carrying the mutation: BRCA 2 4258_4263delinsC (p.Asn1344Hisfs)

From: Mutational analysis of BRCA1 and BRCA2 in hereditary breast and ovarian cancer families from Asturias (Northern Spain)

Family.individual Sex Age Tumor Histopathology Stage Grade ER PgR HER2
27.1 F 52 Br IDC I 3 Neg Neg -
   60 Ov Serous IC - - - -
27.2 F 32 Br IDC IIB 3 Neg Neg Pos
27.3 M 60 Es Squamous III - - - -
208.1 F 50 Br ILC ND - - - -
   57 Br IDC ND - - - -
208.2 F 74 Br - IIIB - - - -
331.1 F 48 Ov Serous IV 3 - - -
331.2 F 49 Br ILC I   Pos Pos Neg
424.1 F 50 Ov Serous IC 2 - - -
609.1 F 43 Br IDC IIIA - Pos Pos Neg
   43 Br DCIS   - - - -
795.1 F 42 Br IDC IIA - Pos Pos -
795.2 F 39 Br IDC IV - Pos Pos -
  1. Age age of cancer diagnosis, F female, M male, Br breast cancer, Ov ovarian cancer, Es esophagus cancer, IDC invasive ductal carcinoma, ILC invasive lobular carcinoma, DCIS ductal carcinoma in situ. ER estrogen receptor status, PR progesterone receptor status, Her2 Her2Neu status, - not applicable or no data, Neg negative, Pos positive.