Figure 1

Map of Asturias showing the geographical origin of the families with the two most frequent novel BRCA1 and BRCA2 mutations. Two main linguistic areas are separated by a solid line while dialect boundaries are separated by dotted lines (based in map created with data from dialectologists Zamora-Vicente and Fernandez-Rei). BRCA1 c.2900_2901dupCT mutation can be related to a transhumance population established in the vicinities of a Roman pathway of historical importance while c.4030_4035delinsC BRCA2 is closely associated to Eonavian dialect population.