Table 2 In vitro cytotoxicity assay in CDDP-sensitive and -resistant gastric cancer cell lines
MKN28 | Resistance factor | IC50(μM) | |
|---|---|---|---|
| Â | Â | MKN28(0) | MKN28(CDDP) |
[PdCl2(L)] | 1.02 | 78.9 ± 4.0 | 80.8 ± 6.6 |
L-OHP | 1.19 | 46.4 ± 4.0 | 55.2 ± 3.8 |
[PtCl2(L)] | 2.54 | 111.7 ± 27.1 | 283.9 ± 19.3 |
CDDP | 3.37 | 19.4 ± 2.4 | 65.4 ± 4.6 |
CABDA | 4.33 | 202.9 ± 17.2 | 878.3 ± 34.1 |
MKN45 | Resistance factor | IC50(μM) | |
| Â | Â | MKN45(0) | MKN45(CDDP) |
[PdCl2(L)] | 1.14 | 61.2 ± 6.8 | 69.7 ± 4.1 |
L-OHP | 1.3 | 27.3 ± 1.1 | 35.6 ± 6.7 |
[PtCl2(L)] | 2.18 | 129.5 ± 14.8 | 282.6 ± 34.5 |
CDDP | 3.27 | 23.5 ± 2.2 | 77.0 ± 8.5 |
CABDA | 3.42 | 152.8 ± 3.7 | 522.0 ± 27.4 |