Skip to main content

Table 3 Associations between candidate genes and glioma risk

From: Genetic polymorphisms of DNA double-strand break repair pathway genes and glioma susceptibility

Genotype

Cases, n(%)

Controls, n(%)

OR (95% CI)a

P trend b

P value for HWE test

XRCC3: rs861539 (T241M)

CC

336 (87.5)

340 (88.5)

1.00

0.835

0.165

CT

47 (12.2)

41 (10.7)

1.15 (0.73-1.79)

  

TT

1 (0.3)

3 (0.8)

0.33 (0.03-3.22)

  

XRCC3: rs1799794 (−4541G>A)

GG

100 (26.0)

108 (28.1)

1.00

0.838

0.271

GA

201 (52.4)

181 (47.1)

1.09 (0.78-1.53)

  

AA

83 (21.6)

95 (24.8)

0.86 (0.57-1.28)

  

XRCC3: rs1799796 (A17893G)

AA

178 (46.4)

171 (44.5)

1.00

0.231

0.406

AT

173 (45.0)

165 (43.0)

0.97 (0.72-1.31)

  

TT

33 (8.6)

48 (12.5)

0.64 (0.39-1.04)

  

BRCA2: rs1799943 (−26G>A)

GG

158 (41.2)

180 (46.9)

1.00

0.149

0.722

GA

186 (48.4)

168 (43.7)

1.22 (0.90-1.64)

  

AA

40 (10.4)

36 (9.4)

1.22 (0.74-2.01)

  

BRCA2: rs15869 (3' UTR)

AA

213 (55.5)

220 (57.3)

1.00

0.646

0.375

AC

143 (37.2)

137 (35.7)

1.05 (0.78-1.42)

  

CC

28 (7.3)

27 (7.0)

1.04 (0.59-1.83)

  

RAG1: rs2227973 (R820K)

GG

129 (33.6)

134 (34.9)

1.00

1.000

0.586

GA

200 (52.1)

190 (49.5)

0.96 (0.70-1.30)

  

AA

55 (14.3)

60 (15.6)

0.83 (0.54-1.29)

  

XRCC5: rs1051685 (3' UTR)

AA

313 (81.5)

326 (84.9)

1.00

0.232

0.808

AG

69 (18.0)

56 (14.6)

1.24 (0.84-1.82)

  

GG

2 (0.5)

2 (0.5)

1.00 (0.37-2.68)

  

LIG4: rs1805388 (T9I)

CC

163 (42.4)

222 (57.8)

1.00

< 0.001

0.659

CT

172 (44.8)

142 (37.0)

1.62 (1.20-2.18)

  

TT

49 (12.8)

20 (5.2)

3.27 (1.87-5.71)

  

XRCC4: rs1805377 (Splice Site)

AA

179 (46.6)

195 (50.8)

1.00

0.030

0.454

AG

143 (37.2)

153 (39.8)

0.96 (0.71-1.30)

  

GG

62 (16.2)

36 (9.4)

1.77 (1.12-2.80)

  

ATM: rs189037 (−111G/A)

GG

140 (36.5)

125 (32.5)

1.00

0.487

0.070

GA

186 (48.4)

203 (52.9)

0.78 (0.57-1.07)

  

AA

58 (15.1)

56 (14.6)

0.88 (0.57-1.37)

  
  1. aAdjusted for age, gender, smoking and drinking status.
  2. bFalse Discovery Rate (FDR) corrected P-value.
  3. P < 0.05 for bold significances.