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Figure 8 | BMC Cancer

Figure 8

From: Cisplatin-induced caspase activation mediates PTEN cleavage in ovarian cancer cells: a potential mechanism of chemoresistance

Figure 8

Pre-treatment with caspase inhibitor restores PTEN levels. (A) A2780 cells were pre-treated with broad range caspase inhibitor (Z-DEVD-FMK) for 1hr at concentration of 20μM followed by 10μM cisplatin treatment for 24hrs. (B) A2780 cells were pre-treated with caspase-3 inhibitor (40 μM) for 1hr followed by 10μM cisplatin treatment for 24hrs. (C) A2780 cells were pre-treated with caspase-6 inhibitor (40 μM) for 1hr followed by 10μM cisplatin treatment for 24hrs. (D) A2780 cells were pre-treated with caspase-8 inhibitor (40 μM) for 1hr followed by 10μM cisplatin treatment for 24hrs. Protein levels were analyzed using western blot analysis. GAPDH was used as a loading control.

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