Figure 4From: Cisplatin-induced caspase activation mediates PTEN cleavage in ovarian cancer cells: a potential mechanism of chemoresistance Cisplatin treatment of ovarian cancer cells does not induce proteasomal degradation of PTEN. A2780 cells were pre-treated with 1 μM and 2 μM of proteasome inhibitor (MG-132) for 1 hr followed by cisplatin (10μM) treatment for 24 hrs. Protein levels were analyzed using western blotting. GAPDH was used as a loading control.Back to article page