Figure 6From: Chronic inhibition of tumor cell-derived VEGF enhances the malignant phenotype of colorectal cancer cells Increase in spheroid formation ability in the mAb-long cells and VEGF-KO cells. The mAb-long cells (A) or the VEGF-KO cells (B) were cultured for 6 days in a 3-D spheroid cell culture system in the absence or presence of VEGFR-TKI. Then, the number of spheroids were counted (n=5, means ± S.D.).Back to article page