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Table 3 Adjusted HRs of all-cause mortality associated with race (black women vs. white women)

From: Mortality risk of black women and white women with invasive breast cancer by hormone receptors, HER2, and p53 status

 

White

Black

Model 1a

Model 2a,b

 

Person-years

Death (No.)

Person-years

Death (No.)

HR

95% CI

HR

95% CI

All women

6246

155

4471

180

1.65

1.32 to 2.06

1.42

1.13 to 1.78

Subtypes defined by ER/PR/HER2

       

 TN

1341

50

1381

66

1.25

0.85 to 1.84

1.12

0.76 to 1.66

 Luminal A

3853

75

2235

70

1.75

1.25 to 2.46

1.54

1.09 to 2.18

 Luminal B

643

16

481

16

1.74

0.70 to 4.31

1.07

0.32 to 3.53

 HER2-enriched

408

14

375

28

2.69

1.06 to 6.85

2.41

0.90 to 6.40

Subtypes defined by ER/PR/HER2/p53

       

 TN/p53-

825

26

664

34

1.45

0.82 to 2.54

1.38

0.77 to 2.49

 TN/p53+

516

24

717

32

1.04

0.58 to 1.88

1.04

0.57 to 1.89

 Luminal A/p53-

3262

55

1814

52

1.73

1.16 to 2.58

1.62

1.08 to 2.43

 Luminal A/p53+

591

20

421

18

1.45

0.60 to 3.54

0.99

0.37 to 2.70

Younger women (ages 35–49 yrs)

3066

90

2248

95

1.49

1.10 to 2.01

1.27

0.94 to 1.73

Subtypes defined by ER/PR/HER2

       

 TN

861

34

785

43

1.36

0.84 to 2.18

1.16

0.71 to 1.89

 Luminal A

1623

36

1069

28

1.33

0.79 to 2.23

1.20

0.71 to 2.03

Subtypes defined by ER/PR/HER2/p53

       

 TN/p53-

513

18

372

21

1.44

0.72 to 2.87

1.43

0.70 to 2.90

 TN/p53+

349

16

413

22

1.21

0.60 to 2.47

1.13

0.54 to 2.36

 Luminal A/p53-

1329

28

792

17

1.06

0.56 to 2.01

1.05

0.54 to 2.02

 Luminal A/p53+

294

8

277

11

1.32

0.32 to 5.42

0.92

0.21 to 4.06

Older women (ages 50–64 yrs)

3181

65

2223

85

1.89

1.36 to 2.62

1.62

1.17 to 2.26

Subtypes defined by ER/PR/HER2

       

 TN

480

16

596

23

1.04

0.54 to 2.02

1.07

0.55 to 2.11

 Luminal A

2231

39

1167

42

2.21

1.40 to 3.47

1.88

1.18 to 2.99

Subtypes defined by ER/PR/HER2/p53

       

 TN/p53-

313

8

292

13

1.66

0.61 to 4.54

1.48

0.50 to 4.41

 TN/p53+

167

8

304

10

0.77

0.27 to 2.20

0.79

0.27 to 2.30

 Luminal A/p53-

1934

27

1022

35

2.49

1.47 to 4.22

2.22

1.30 to 3.79

 Luminal A/p53+

297

12

144

7

1.54

0.48 to 4.91

1.44

0.25 to 8.11

  1. HRs are from multivariable Cox proportional hazards regression models using age (in days) at diagnosis and at death or end of follow-up as the time scale and stratified by single years of age at diagnosis. aAdjusted for study site. bAdditionally adjusted for tumor stage. Abbreviations: HR, hazard ratio; CI, confidence interval. ER, estrogen receptor; PR, progesterone receptor; HER, human epidermal growth factor receptor; TN, triple negative. Note: TN = ER-/PR-/HER2-, Luminal A = ER+ or PR+ plus HER2-, Luminal B = ER+ or PR+ plus HER2+, HER2-enriched = ER-/PR-/HER2+.
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BMC Cancer

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