| All women | Younger women | Older women | ||||||
---|---|---|---|---|---|---|---|---|---|
(ages 35–49 y) | (ages 50–64 y) | ||||||||
 | White | Black | P a | White | Black | P a | White | Black | P a |
 | n=681 | n=523 |  | n=345 | n=272 |  | n=336 | n=251 |  |
Study site | Â | Â | 0.01 | Â | Â | 0.07 | Â | Â | 0.09 |
 Los Angeles | 66.7 | 73.2 |  | 64.9 | 71.7 |  | 68.5 | 74.9 |  |
 Detroit | 33.3 | 26.8 |  | 35.1 | 28.3 |  | 31.6 | 25.1 |  |
Age at diagnosis, years | Â | Â | 0.004 | Â | Â | <0.001 | Â | Â | Â |
 35-39 | 21.4 | 14.2 |  | 42.3 | 27.2 |  | - | - |  |
 40-44 | 15.9 | 19.5 |  | 31.3 | 37.5 |  | - | - |  |
 45-49 | 13.4 | 18.4 |  | 26.4 | 35.3 |  | - | - |  |
 50-54 | 18.7 | 17.6 |  | - | - |  | 37.8 | 36.7 | 0.42 |
 55-59 | 14.5 | 16.4 |  | - | - |  | 29.5 | 34.3 |  |
 60-64 | 16.2 | 14.0 |  | - | - |  | 32.7 | 29.1 |  |
ER status | Â | Â | <0.001 | Â | Â | 0.05 | Â | Â | <0.001 |
 ER- | 36.9 | 48.8 |  | 46.4 | 54.4 |  | 27.1 | 42.6 |  |
 ER+ | 63.1 | 51.2 |  | 53.6 | 45.6 |  | 72.9 | 57.4 |  |
PR status | Â | Â | <0.001 | Â | Â | <0.001 | Â | Â | <0.001 |
 PR- | 38.5 | 52.4 |  | 42.6 | 54.0 |  | 34.2 | 50.6 |  |
 PR+ | 61.5 | 47.6 |  | 57.4 | 46.0 |  | 65.8 | 49.4 |  |
HER2 status | Â | Â | 0.16 | Â | Â | 0.98 | Â | Â | 0.04 |
 HER2- | 83.3 | 80.1 |  | 81.2 | 81.3 |  | 85.4 | 78.9 |  |
 HER2+ | 16.7 | 19.9 |  | 18.8 | 18.7 |  | 14.6 | 21.1 |  |
Subtypes defined by ER/PR/HER2 | Â | Â | <0.001 | Â | Â | 0.12 | Â | Â | <0.001 |
 TN | 23.8 | 33.5 |  | 30.4 | 39.0 |  | 17.0 | 27.5 |  |
 Luminal A | 59.5 | 46.7 |  | 50.7 | 42.3 |  | 68.5 | 51.4 |  |
 Luminal B | 9.8 | 10.3 |  | 11.0 | 9.9 |  | 8.6 | 10.8 |  |
 HER2-enriched | 6.9 | 9.6 |  | 7.8 | 8.8 |  | 6.0 | 10.4 |  |
p53 status | Â | Â | <0.001 | Â | Â | Â | Â | Â | 0.003 |
 p53- | 77.0 | 65.8 |  | 72.5 | 61.0 | 0.003 | 81.6 | 70.9 |  |
 p53+ | 23.0 | 34.2 |  | 27.5 | 39.0 |  | 18.4 | 29.1 |  |
Subtypes defined by ER/PR/HER2/p53 | Â | Â | <0.001 | Â | Â | 0.03 | Â | Â | <0.001 |
 TN/p53- | 14.4 | 16.6 |  | 18.0 | 18.8 |  | 10.7 | 14.3 |  |
 TN/p53+ | 9.4 | 16.8 |  | 12.5 | 20.2 |  | 6.3 | 13.2 |  |
 Luminal A/p53- | 49.9 | 37.7 |  | 41.5 | 31.3 |  | 58.6 | 44.6 |  |
 Luminal A/p53+ | 9.5 | 9.0 |  | 9.3 | 11.0 |  | 9.8 | 6.8 |  |
 Luminal B/p53- | 8.1 | 6.0 |  | 8.4 | 5.2 |  | 7.7 | 6.8 |  |
 Luminal B/p53+ | 1.8 | 4.4 |  | 2.6 | 4.8 |  | 0.9 | 4.0 |  |
 HER2-enriched/p53- | 4.6 | 5.5 |  | 4.6 | 5.9 |  | 4.5 | 5.2 |  |
 HER2-enriched/p53+ | 2.4 | 4.0 |  | 3.2 | 2.9 |  | 1.5 | 5.2 |  |
Stage | Â | Â | <0.001 | Â | Â | 0.007 | Â | Â | 0.001 |
 Localized | 63.1 | 51.1 |  | 56.5 | 45.6 |  | 69.9 | 57.0 |  |
 Non-localized | 36.9 | 49.0 |  | 43.5 | 54.4 |  | 30.1 | 43.0 |  |
Grade | Â | Â | <0.001 | Â | Â | 0.006 | Â | Â | <0.001 |
 Low | 12.5 | 8.6 |  | 9.6 | 6.6 |  | 15.5 | 10.8 |  |
 Intermediate | 63.1 | 53.0 |  | 58.6 | 49.3 |  | 67.9 | 57.0 |  |
 High | 24.4 | 38.4 |  | 31.9 | 44.1 |  | 16.7 | 32.3 |  |