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Figure 2 | BMC Cancer

Figure 2

From: Imatinib mesylate inhibits cell growth of malignant peripheral nerve sheath tumors in vitro and in vivothrough suppression of PDGFR-β

Figure 2

Effects of PDGF-BB and imatinib mesylate on phosphorylation of PDGFRs. PDGFR-β of all six MPNST cell lines was phosphorylated in response to 25 ng/ml of PDGF-BB for 30 min. PDGF-BB stimulation did not induce any phosphorylation of PDGFR-α in all cell lines. Pretreatment with 10 μM imatinib mesylate almost completely suppressed PDGF-BB-induced PDGFR-β phosphorylation in all cell lines.

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BMC Cancer

ISSN: 1471-2407

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