Table 5 Second primary malignancy and recurrence (local/distant) by HPV status
HPV status | All cases | Site of recurrence | Second Primary Malignancy (SPM) | |||||
|---|---|---|---|---|---|---|---|---|
None | H&N | DM | HN + DM | No SPM | SPM H&N | Other SPM | ||
‘True’ negatives (Group 1) p16 negative, PCR & ISH negative | 59 | 39 | 15 | 4 | 1 | 51 | 1 | 7 |
‘Equivocal' (Group 2) p16 negative, PCR &/or ISH positive | 6 | 4 | 1 | 1 | 0 | 5 | 0 | 1 |
‘True’ positives (Group 3) p16 positive, PCR &/or ISH positive | 69 | 57 | 8 | 4 | 0 | 61 | 3 | 5 |
‘Equivocal' (Group 4) p16 positive, PCR & ISH negative | 4 | 2 | 1 | 1 | 0 | 4 | 0 | 0 |
Total | 138 | 102 | 25 | 10 | 1 | 121 | 4 | 13 |