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Table 2 Estimation of false negatives among 55 HMBS negative cases

From: Human Papillomavirus-associated oropharyngeal cancer: an observational study of diagnosis, prevalence and prognosis in a UK population

HPV marker

Observed HPV positives among

Chi-square test for association between observed HPV status and HMBS

Estimated false negatives for HPV among 55 HMBS negative cases

HMBS positive n = 83

HMBS negative n = 55

Number

As proportion of 55 HMBS negative cases

95% confidence interval

GP5+/6+ PCR

49 (59%)

20 (36%)

p = 0.009

12.5

23%

6% to 38%

ISH

42 (51%)

18 (33%)

p = 0.04

9.8

18%

1% to 33%

p16

47 (57%)

26 (47%)

p = 0.28

5.1

9%

0%* to 26%

  1. For GP5+/6+ PCR, number of false negatives estimated as 49 × 55/83 – 20 = 12.5, representing 23% of HMBS negative cases. The same method was used to calculate false negative rates for ISH and p16.
  2. *95% confidence interval extends below 0 for p16 – shown truncated here.
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BMC Cancer

ISSN: 1471-2407

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