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Table 4 Summary results for efficacy variables

From: Phase II trial of neoadjuvant pemetrexed plus cisplatin followed by surgery and radiation in the treatment of pleural mesothelioma

  

Before PAa

After PA

Overall

EFS b

    
 

Median

6.3 (3.3-10.5)

8.1 (4.1 - 19.7)

6.9 (5.0-10.5)

 

1-year Rate

23.8 (8.2-47.2)

39.4 (22.9-57.9)

33.3 (21.1-47.5)

 

2-year Rate

14.3 (3.6-32.1)

30.3 (15.9-46.1)

24.1 (13.7-36.0)

PFS c

    
 

Median

6.6 (5.0-11.0)

11.9 (6.9-26.9)

8.6 (6.3-14.4)

 

1-year Rate

28.6 (11.7-48.2)

48.5 (30.8-64.1)

40.7 (27.7-53.4)

 

2-year Rate

19.1 (5.9-37.7)

39.4 (23.1-55.4)

31.5 (19.7-43.9)

OS d

    
 

Median

12.6 (6.9-21.1)

NA

15.5 (11.0-NA)

TTR e

    
 

Median

2.8 (1.4-5.1)

7.6 (4.1-8.9)

4.8 (2.5-8.0)

  1. a Protocol Amendment; b Event-free Survival; c Progression-free Survival; d Overall Survival; e Time to Tumor Response.
  2. Overall results are presented as well as results stratified by time of enrollment in the study with respect to the protocol amendment. Results are expressed in months (95% CI) for median variables and as percentage (95% CI) for 1- and 2-year rates.