Figure 1

Study design and patients disposition adopted in this study. Study design highlights the trimodality therapy adopted: patients disposition is provided for patients enrolled before the protocol amendment (PA) as well as for those enrolled after PA and overall. Trimodality therapy was considered completed for those patients who received ≥28 doses of radiotherapy (RT) while the study was considered completed for those subjects completing RT and the 90-day post-radiation follow-up. pts = patients; MPM = malignant pleural mesothelioma; HTR = hemithoracic radiation; EPP = extrapleural pneumonectomy; BA = before amendment; AA = post amendment.