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Table 3 Risk of ductal and luminal breast cancer associated with SNPs in TLR or NFκB pathway genes

From: Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study

  Maj/Min Allele Controls (n = 807) Ductal (n = 565) OR 95% CI Gene wideP Luminal (n = 744) OR 95% CI Gene wide P
  0 1 2 0 1 2      0 1 2  
MAP3K1            0.01        0.003
 rs889312 A/C 434 318 49 281 220 60 1.24 1.04 1.46   361 301 77 1.27 1.08 1.48  
MMP9            0.02        0.02
 rs17576 A/G 366 357 78 216 276 67 1.24 1.05 1.46   296 340 100 1.23 1.06 1.43  
 rs2274756 G/A 611 178 12 424 129 8 1.03 0.82 1.29   541 183 15 1.17 0.95 1.44  
 rs3918262 A/G 518 246 31 327 195 35 1.29 1.08 1.56   444 248 40 1.20 1.01 1.43  
TANK            0.002        0.004
 rs17705608 A/G 263 404 134 230 256 75 0.78 0.67 0.92   284 358 97 0.82 0.71 0.95  
 rs7568498 A/C 558 208 35 385 161 15 0.98 0.80 1.19   495 223 21 1.04 0.87 1.25  
 rs1921310 A/G 449 303 49 347 191 23 0.80 0.67 0.96   446 261 32 0.84 0.71 1.00  
 rs1267074 T/A 397 310 94 251 253 56 1.07 0.91 1.26   326 336 76 1.09 0.94 1.27  
 rs1267034 A/G 623 159 19 412 137 12 1.19 0.95 1.48   546 176 17 1.17 0.96 1.44  
 rs7309 A/G 196 392 212 179 264 118 0.78 0.67 0.91   216 375 148 0.80 0.69 0.92  
TLR9            0.14        0.09
 rs352140 A/G 219 391 191 180 268 113 0.85 0.73 0.99   234 359 146 0.85 0.74 0.98  
 rs187084 A/G 302 362 137 190 254 117 1.16 1.00 1.34   254 337 148 1.13 0.98 1.30  
  1. aAll models are log-additive and adjusted for continuous linear age at reference.