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Table 2 Risk of breast cancer associated with SNPs in TLR or NFκB pathway genes

From: Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study

Function Maj/Min Allele Controls (n = 807) Cases (n = 845) OR 95% CI p SNP perm p Gene wide p
  0 1 2 0 1 2  
MAP3K1 (chr 5: 56146657 - 56227736)               0.006
 rs889312 Intergenic A/C 434 318 49 417 337 86 1.24 1.06 1.44 0.006 0.006  
MMP9 (chr 20: 44070954 - 44078607)               0.03
 rs17576 Coding: Q279R A/G 366 357 78 338 393 106 1.21 1.04 1.40 0.01 0.03  
 rs2274756 Coding: R668Q, R668P G/A 611 178 12 619 204 17 1.14 0.94 1.40 0.19 -  
 rs3918262 Intron A/G 518 246 31 507 282 43 1.18 1.00 1.40 0.05 0.11  
TANK (chr 2: 161701712 - 161800928)               0.04
 rs17705608 Flanking 5′ UTR A/G 263 404 134 321 406 113 0.83 0.72 0.96 0.01 0.05  
 rs7568498 Intron A/C 558 208 35 569 244 27 1.03 0.86 1.22 0.78 -  
 rs1921310 Intron A/G 449 303 49 504 300 36 0.85 0.72 1.00 0.05 0.17  
 rs1267074 Intron T/A 397 310 94 382 373 84 1.05 0.91 1.22 0.48 -  
 rs1267034 Intron A/G 623 159 19 631 191 18 1.11 0.91 1.35 0.31 -  
 rs7309 3′ UTR A/G 196 392 212 240 421 179 0.83 0.73 0.95 0.008 0.04  
TLR9 (chr 3: 52230138 - 52235219)               0.03
 rs352140 Coding: P545P A/G 219 391 191 267 406 167 0.85 0.74 0.97 0.02 0.03  
 rs187084 Flanking 5′ UTR A/G 302 362 137 290 381 169 1.13 0.98 1.29 0.08 0.08  
  1. aAll models are log-additive and adjusted for continuous linear age at reference.
  2. bPermutation p-values that are not significant according to the Holm multiple test procedure [38] are not presented.