Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study

BMC Cancer

Table 2 Risk of breast cancer associated with SNPs in TLR or NFκB pathway genes

Function		Maj/Min Allele	Controls (n = 807)			Cases (n = 845)			OR	95% CI		p	SNP perm p	Gene wide p
			0	1	2	0	1	2
MAP3K1 (chr 5: 56146657 - 56227736)														0.006
rs889312	Intergenic	A/C	434	318	49	417	337	86	1.24	1.06	1.44	0.006	0.006
MMP9 (chr 20: 44070954 - 44078607)														0.03
rs17576	Coding: Q279R	A/G	366	357	78	338	393	106	1.21	1.04	1.40	0.01	0.03
rs2274756	Coding: R668Q, R668P	G/A	611	178	12	619	204	17	1.14	0.94	1.40	0.19	-
rs3918262	Intron	A/G	518	246	31	507	282	43	1.18	1.00	1.40	0.05	0.11
TANK (chr 2: 161701712 - 161800928)														0.04
rs17705608	Flanking 5′ UTR	A/G	263	404	134	321	406	113	0.83	0.72	0.96	0.01	0.05
rs7568498	Intron	A/C	558	208	35	569	244	27	1.03	0.86	1.22	0.78	-
rs1921310	Intron	A/G	449	303	49	504	300	36	0.85	0.72	1.00	0.05	0.17
rs1267074	Intron	T/A	397	310	94	382	373	84	1.05	0.91	1.22	0.48	-
rs1267034	Intron	A/G	623	159	19	631	191	18	1.11	0.91	1.35	0.31	-
rs7309	3′ UTR	A/G	196	392	212	240	421	179	0.83	0.73	0.95	0.008	0.04
TLR9 (chr 3: 52230138 - 52235219)														0.03
rs352140	Coding: P545P	A/G	219	391	191	267	406	167	0.85	0.74	0.97	0.02	0.03
rs187084	Flanking 5′ UTR	A/G	302	362	137	290	381	169	1.13	0.98	1.29	0.08	0.08

^aAll models are log-additive and adjusted for continuous linear age at reference.
^bPermutation p-values that are not significant according to the Holm multiple test procedure [38] are not presented.

ISSN: 1471-2407