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Table 1 Association of Aurora A mRNA expression, gene copy number and protein expression with clinicopathological parameters

From: A comprehensive analysis of Aurora A; transcript levels are the most reliable in association with proliferation and prognosis in breast cancer

Clinical parameters

No. of patients

Aurora A mRNA expression

Aurora A amplification

Aurora A protein expression

Median(25%, 75%)

P

Negative(%)

Positive (%)

P

Negative(%)

Positive(%)

P

Age(years)

             

<50

65

0.20 (0.08, 0.46)

0.67*

42

(65)

23

(35)

0.14‡

47

(72)

18

(28)

0.49‡

≥50

213

0.16 (0.07, 0.43)

158

(74)

55

(26)

163

(77)

50

(23)

Menopause

             

Pre-

73

0.18 (0.07, 0.42)

0.89*

50

(68)

23

(32)

0.45‡

54

(74)

19

(26)

0.72‡

Post-

205

0.16 (0.08, 0.45)

150

(73)

55

(27)

156

(76)

49

(24)

Tumor size (mm)

             

≤20

124

0.16 (0.08 , 0.36)

0.25*

97

(78)

27

(22)

0.035‡

99

(80)

25

(20)

0.13‡

>20

154

0.18 (0.08, 0.52)

103

(67)

51

(33)

111

(72)

43

(28)

Nodal status

             

-

165

0.16 (0.06, 0.38)

0.14*

125

(76)

40

(24)

0.089‡

134

(81)

31

(19)

0.0083‡

+

113

0.17 (0.09, 0.52)

75

(66)

38

(34)

76

(67)

37

(33)

Nuclear grade

             

1

143

0.14 (0.06, 0.27)

0.0004†

114

(80)

29

(20)

0.0044‡

123

(86)

20

(14)

<0.0001‡

2

66

0.22 (0.10, 0.57)

38

(58)

28

(42)

45

(68)

21

(32)

3

68

0.31 (0.10, 0.76)

48

(71)

20

(29)

41

(60)

27

(40)

ER

             

-

61

0.20 (0.09, 0.66)

0.14*

43

(70)

18

(30)

0.78‡

38

(62)

23

(38)

0.0084‡

+

217

0.16 (0.08, 0.40)

157

(72)

60

(28)

172

(79)

45

(21)

PgR

             

-

94

0.23 (0.10, 0.56)

0.016*

71

(76)

23

(24)

0.34‡

67

(71)

27

(29)

0.24‡

+

184

0.14 (0.06, 0.38)

129

(70)

55

(30)

143

(78)

41

(22)

HER2

             

-

236

0.16(0.08, 0.42)

0.86*

169

(72)

67

(28)

0.77‡

183

(76)

53

(22)

0.075‡

+

42

0.15(0.08, 0.48)

31

(74)

11

(26)

27

(64)

15

(36)

Ki67

             

≦15%

91

0.11(0.06, 0.20)

<0.0001*

74

(81)

17

(18)

0.013‡

79

(87)

12

(13)

0.0015‡

> 15%

187

0.25(0.10, 0.58)

126

(67)

61

(32)

131

(70)

56

(30)

Tumor Subtype

             

ER+/HER2-

205

0.16(0.07, 0.39)

0.084†

150

(73)

55

(27)

0.39‡

162

(79)

43

(21)

0.082‡

ER+ or –/HER2+

42

0.15(0.08, 0.48)

31

(74)

11

(26)

27

(64)

15

(36)

ER-/HER2- (Triple Negative)

31

0.29(0.10, 0.79)

19

(61)

12

(39)

21

(68)

10

(32)

  1. Statistical methods; *:Wilcoxon test, †:Kruskal-Wallis test, ‡χ2-test.