Figure 1

Strategy to investigate efficacy of AIs in lung tumors in Kras ^G12D-LSL . A To investigate efficacy of AIs in lung tumors in Kras^G12D-LSL, mice were intranasally inhaled with Adeno-Cre and monitored at 8 wks after inhalation by histology analyses of few lungs from the recipients. All the remaining mice were randomized into groups for treatment with AIs (PF-210, axitinib and sunitinib) at 14 wks after Adeno-Cre administration when majority of animals develop malignant lesions in the lung. At 8 weeks after treatment, all the lungs from the treated mice were histologically analyzed. B Representative Images of lung lesions at 8 and 14 wks after Adeno-Cre administration compared to a lung isolated from a wild type mouse.