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Table 3 Important Predictors of VTEs in the 12 months after RCC diagnosis, SEER-Medicare Data (1991–2003) a

From: Older renal cell cancer patients experience increased rates of venous thromboembolic events: a retrospective cohort study of SEER-Medicare data

n = 11,950 RCC patients

DVTb(n = 990)

P-Value

PEb(n = 286)

P-Value

OTEb(n = 470)

P-Value

 

HR (95% CI)

 

HR (95% CI)

 

HR (95% CI)

 

Male sex

0.8 (0.7-0.9)

<0.001

0.8 (0.6- 1.0)

0.041

--

--

Atherosclerosis

2.0 (1.7-2.3)

<0.001

2.5 (2.0-3.2)

<0.001

1.7 (1.4-2.1)

<0.001

Diabetes

1.2 (1.1-1.4)

0.004

--

--

--

--

Hypercholesterolemia

--

--

--

--

1.3 (1.1-1.6)

0.012

Kidney disease

1.9 (1.6-2.1)

<0.001

1.6 (1.2- 2.0)

<0.001

1.4 (1.2-1.7)

0.001

Varicose veins

2.2 (1.6-3.1)

<0.001

--

--

--

--

History of cancer diagnosis

--

--

1.5 (1.0- 2.2)

0.033

--

--

History of VTEc

5.4 (4.4-6.4)

<0.001

20.1 (13.8-29.2)

<0.001

7.6 (5.9-9.9)

<0.001

Chemotherapy

1.8 (1.4-2.2)

<0.001

--

--

1.4 (1.0-2.0)

0.048

Central venous catheterd

0.4 (0.3-0.4)

<0.001

0.3 (0.2-0.5)

<0.001

0.5 (0.4-0.7)

<0.001

High-risk surgerye

0.4 (0.3-0.6)

<0.001

0.5 (0.3-0.8)

0.003

0.5 (0.4-0.7)

<0.001

Stage

      

Regional versus localized

2.5 (2.2-2.9)

<0.001

1.6 (1.2-2.1)

0.002

2.6 (2.1-3.2)

<0.001

Distant versus localized

2.6 (2.2-3.0)

<0.001

1.9 (1.4-2.5)

<0.001

1.7 (1.3-2.2)

<0.001

  1. aAll models adjusted for age and race (age and race were not statistically significant predictors of any VTEs).
  2. bDVT = Deep Vein Thrombosis; PE = Pulmonary Embolism; OTE = Other thromboembolic event. OTE category includes the following diagnoses: central retinal vein occlusion, venous tributary (branch) occlusion, Nonpyogenic thrombosis of intracranial venous sinus, phlebitis/thrombophlebitis of superficial vessels of lower extremities, phlebitis/thrombophlebitis of superficial veins of upper extremities, phlebitis/thrombophlebitis of other sites, gout with other specified manifestations, Budd-Chiari syndrome, and venous embolism/thrombosis of renal vein.
  3. cHistory of VTE in the 12 months before RCC diagnosis.
  4. dCentral venous catheter (CVC) in the 12 months after diagnosis. CVCs that occurred less than 30 days before a TE event were excluded.
  5. eHigh-risk surgery = cardiac or vascular surgeries in the year after RCC diagnosis. Procedures that happened less than 30 days before a TE event were excluded because of the nature of Medicare claims (Date ranges are used for procedures as we wanted to make sure that the procedure was not part of the treatment for the VTE outcome of interest).