Parameter | huKS-IL2 dosing cohort, mg/m2 | ||||
---|---|---|---|---|---|
0.5 | 1.0 | 2.0 | 3.0 | 4.0 | |
(n = 3) | (n = 4) | (n = 6) | (n = 6) | (n = 7) | |
Cmax, ng/mL | |||||
Mean (%CV) | 132.6 (8.9) | 316.4 (12.1) | 567.6 (52.6) | 1252.9 (24.8) | 1323.9 (26.9) |
Min-Max | 119.1–141.0 | 268.6–350.0 | 295.4–1052.0 | 888.1–1712.0 | 897.3–1687.9 |
AUC0-24h, ng/mL•h | |||||
Mean (%CV) | 724.8 (16.5) | 2989.7 (59.4) | 4850.9 (106.1) | 13329.1 (59.7) | 12332.5 (28.7) |
Min-Max | 593.0–826.8 | 1344.6–5374.7 | 1184.4–14596.4 | 6686.3–28917.9 | 7236.1–16825.5 |
AUC0-∞, ng/mL•h | |||||
Mean (%CV) | 823.4 (22.4) | 3849.4 (84.9) | 6440.9 (128.7) | 19769.3 (112.1) | 13083.9 (30.0) |
Min-Max | 627.8–993.9 | 1406.5–1921.7 | 1179.8–22682.1 | 6464.9–64645.7 | 7418.1–18043.6 |
t1/2, h | |||||
Mean (%CV) | 2.7 (20.1) | 6.5 (92.4) | 4.4 (115.9) | 8.5 (100.1) | 5.1 (16.4) |
Min-Max | 2.1–3.2 | 2.0–13.3 | 0.9–14.4 | 3.2–25.6 | 4.0–6.0 |
CL, L/h | |||||
Mean (%CV) | 1.24 (40.2) | 0.84 (75.7) | 1.81 (78.4) | 0.49 (59.7) | 0.66 (41.1) |
Min-Max | 0.83–1.79 | 0.26–1.72 | 0.20–3.27 | 0.08–0.97 | 0.32–1.09 |