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Table 1 Murine anti-human PSA IgG1 titers in the serum of vaccinated human FcεRIα transgenic mice

From: A novel IgE antibody targeting the prostate-specific antigen as a potential prostate cancer therapy

Titers 14 days after initial immunization

Mouse #

PSA + anti-PSA IgE

PSA + anti-PSA IgG1

PSA

Buffer

1

8,100

100

900

0

2

2,700

24,300

0

0

3

900

8,100

0

0

4

2,700

24,300

0

0

5

2,700

24,300

2,700

0

6

900

72,900

8,100

0

7

24,300

8,100

900

0

8

900

2,700

900

0

Median

2,700

16,200

900

0

Titers 13 days after booster (28 days after initial immunization)

Mouse #

PSA + anti-PSA IgE

PSA + anti-PSA IgG1

PSA

Buffer

1

218,700

8,100

24,300

0

2

218,700

72,900

0

0

3

72,900

24,300

0

0

4

218,700

218,700

0

0

5

72,900

400,000

218,700

0

6

72,900

218,700

218,700

0

7

24,300

218,700

8,100

0

8

218,700

24,300

72,900

0

Median

145,800

145,800

16,200

0

  1. Data shown are combined from two independent experiments (n = 4) with a total of 8 animals per group. Sera were serially diluted 3-fold starting at 1:100. Titer was determined as the highest dilution from which a positive signal was obtained.