Figure 5
From: A novel IgE antibody targeting the prostate-specific antigen as a potential prostate cancer therapy
Vaccination study in human FcεRIα transgenic mice. Survival plot of human FcεRIα transgenic mice vaccinated subcutaneously in the left flank with PSA alone (4 μg) or complexed in a 1:1 molar ration to either the anti-PSA IgE or IgG1. Mice were given a booster on day 15, also in the left flank. Two-weeks after the booster on day 40, mice were challenged with 106 murine CT26 cells expressing human PSA (CT26-PSA) subcutaneously in the right flank. Animals admininstered with buffer alone were used as negative controls. The survival plot shown is the combined data from 2 independent experiments with a total of 8 mice per group and was generated in GraphPad Prism.