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Table 2 Representative genes significantly up-regulated or down-regulated in response to peretinoin treatment

From: Peretinoin, an acyclic retinoid, improves the hepatic gene signature of chronic hepatitis C following curative therapy of hepatocellular carcinoma

Parametric p-value Ratios (Under/Pre)   Description Symbol GB acc
600 mg 600 mg 300 mg    
Up-regulated genes in response to peretinoin treatment
Retinoid target genes
0.0002 1.85 1.25 Cytochrome P450, family 26, subfamily B, polypeptide 1 CYP26B1 NM_019885
0.004 1.75 1.33 Insulin-like growth factor binding protein 6 IGFBP6 NM_002178
0.005 1.42 1.16 Regulatory factor X-associated ankyrin-containing protein RFXANK NM_134440
0.006 1.33 1.30 Putative lymphocyte G0/G1 switch gene G0S2 NM_015714
0.013 1.54 0.90 Retinol binding protein 1 RBP1 NM_002899
0.014 1.56 0.87 Retinol binding protein 4 RBP4 NM_006744
0.034 1.27 1.07 Retinoic acid induced 3 GPRC5A AI923823
0.040 1.22 1.19 Transglutaminase 2 TGM2 AI962033
0.044 1.23 1.14 CCAAT/enhancer binding protein (C/EBP), alpha CEBPA NM_004364
Interferon-related genes
0.029 1.45 0.93 Guanylate binding protein 1, interferon-inducible, 67kDa GBP1 NM_002053
0.047 1.39 0.94 Interferon-induced protein 44 IFI44 NM_006417
0.048 1.28 1.05 Chemokine (C-X-C motif) ligand 9 CXCL9 NM_002416
Negative regulator of Wnt and TGF-β signaling
0.004 1.54 1.06 BMP and activin membrane-bound inhibitor homolog BAMBI NM_012342
0.008 1.45 1.11 Secreted frizzled-related protein 5 SFRP5 NM_003015
Anti-angiogenesis
0.021 1.37 0.98 Thrombomodulin THBD NM_000361
0.038 1.28 0.99 Protein C receptor, endothelial (EPCR) PROCR NM_006404
Tumor suppressor related
0.029 1.35 0.96 Jumonji domain containing 3 JMJD3 XM_043272
0.029 1.39 0.91 Jumping translocation breakpoint JTB NM_006694
0.034 1.39 1.32 Protein kinase, AMP-activated, alpha 2 catalytic subunit PRKAA2 NM_006252
Down-regurated genes in response to peretinoin treatment
mTOR-related-gene
0.045 0.78 0.94 FK506 binding protein 12-rapamycin associated protein 1 FRAP1 NM_004958
Cytokine and growth factor
0.019 0.77 1.25 Interleukin 13 IL13 NM_002188
0.031 0.74 1.00 Hepatocyte growth factor HGF NM_000601
Tumor progression related
0.011 0.73 0.94 Junctional adhesion molecule 3 JAM3 NM_032801
0.013 0.70 1.00 V-myc myelocytomatosis viral oncogene homolog Myc NM_002467
0.017 0.73 1.12 Src-like-adaptor SLA NM_006748
0.028 0.78 1.10 Cell division cycle 2, G1 to S and G2 to M CDC2 NM_001786
0.030 0.66 0.95 BCL2-associated athanogene BAG1 NM_004323
0.039 0.64 0.93 Chemokine (C-C motif) receptor 9 CCR9 NM_031200
0.043 0.76 1.13 Pre-B-cell leukemia transcription factor 1 PBX1 H08835
  1. The peretinoin-response genes were identified by comparing hepatic gene expression in the pre and under treatment of 6 patients who were treated with 600 mg dose of peretinoin. The fold changes of gene expression are shown in 300 mg and 600 mg dosage respectively.