Table 2 Representative genes significantly up-regulated or down-regulated in response to peretinoin treatment

Up-regulated genes in response to peretinoin treatment

Retinoid target genes

0.0002

1.85

1.25

Cytochrome P450, family 26, subfamily B, polypeptide 1

CYP26B1

NM_019885

0.004

1.75

1.33

Insulin-like growth factor binding protein 6

IGFBP6

NM_002178

0.005

1.42

1.16

Regulatory factor X-associated ankyrin-containing protein

RFXANK

NM_134440

0.006

1.33

1.30

Putative lymphocyte G0/G1 switch gene

G0S2

NM_015714

0.013

1.54

0.90

Retinol binding protein 1

RBP1

NM_002899

0.014

1.56

0.87

Retinol binding protein 4

RBP4

NM_006744

0.034

1.27

1.07

Retinoic acid induced 3

GPRC5A

AI923823

0.040

1.22

1.19

Transglutaminase 2

TGM2

AI962033

0.044

1.23

1.14

CCAAT/enhancer binding protein (C/EBP), alpha

CEBPA

NM_004364

Interferon-related genes

0.029

1.45

0.93

Guanylate binding protein 1, interferon-inducible, 67kDa

GBP1

NM_002053

0.047

1.39

0.94

Interferon-induced protein 44

IFI44

NM_006417

0.048

1.28

1.05

Chemokine (C-X-C motif) ligand 9

CXCL9

NM_002416

Negative regulator of Wnt and TGF-β signaling

0.004

1.54

1.06

BMP and activin membrane-bound inhibitor homolog

BAMBI

NM_012342

0.008

1.45

1.11

Secreted frizzled-related protein 5

SFRP5

NM_003015

Anti-angiogenesis

0.021

1.37

0.98

Thrombomodulin

THBD

NM_000361

0.038

1.28

0.99

Protein C receptor, endothelial (EPCR)

PROCR

NM_006404

Tumor suppressor related

0.029

1.35

0.96

Jumonji domain containing 3

JMJD3

XM_043272

0.029

1.39

0.91

Jumping translocation breakpoint

JTB

NM_006694

0.034

1.39

1.32

Protein kinase, AMP-activated, alpha 2 catalytic subunit

PRKAA2

NM_006252

Down-regurated genes in response to peretinoin treatment

mTOR-related-gene

0.045

0.78

0.94

FK506 binding protein 12-rapamycin associated protein 1

FRAP1

NM_004958

Cytokine and growth factor

0.019

0.77

1.25

Interleukin 13

IL13

NM_002188

0.031

0.74

1.00

Hepatocyte growth factor

HGF

NM_000601

Tumor progression related

0.011

0.73

0.94

Junctional adhesion molecule 3

JAM3

NM_032801

0.013

0.70

1.00

V-myc myelocytomatosis viral oncogene homolog

Myc

NM_002467

0.017

0.73

1.12

Src-like-adaptor

SLA

NM_006748

0.028

0.78

1.10

Cell division cycle 2, G1 to S and G2 to M

CDC2

NM_001786

0.030

0.66

0.95

BCL2-associated athanogene

BAG1

NM_004323

0.039

0.64

0.93

Chemokine (C-C motif) receptor 9

CCR9

NM_031200

0.043

0.76

1.13

Pre-B-cell leukemia transcription factor 1

PBX1

H08835