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Table 11 Meta-analyses of indirect estimates of lung cancer mortality rates in ever smokers

From: Indirectly estimated absolute lung cancer mortality rates by smoking status and histological type based on a systematic review

Sex

Region

Period

Statistica

All lung cancerb

Squamousc

Adenod

All

All

All

n

220

81

81

   

Rate

258.3 (239.6–278.3)

117.0 (102.7–133.3)

58.5 (50.1–68.2)

   

H,PH

244.49, <0.001

83.73, <0.001

52.65, <0.001

Male

  

n

129

43

43

   

Rate

365.9 (334.4–400.4)

185.9 (163.1–211.9)

67.1 (55.3–81.4)

Female

  

n

91

38

38

   

Rate

148.2 (130.5–168.4)

65.2 (54.3–78.4)

49.1 (38.2–63.1)

Betweene

  

PB

<0.001

<0.001

<0.01

 

Canada

 

n

10

4

4

   

Rate

223.4 (153.2–325.7)

162.8 (102.0–259.8)

104.7 (64.3–170.5)

 

USA

 

n

54

25

25

   

Rate

286.7 (246.0–334.2)

115.9 (90.9–147.6)

63.4 (48.3–83.2)

 

SC Americaf

 

n

9

5

5

   

Rate

320.1 (253.8–403.7)

131.9 (92.6–188.0)

88.7 (60.2–130.6)

 

UK

 

n

26

4

4

   

Rate

352.3 (294.5–421.6)

108.7 (52.4–225.7)

18.9 (4.5–79.8)

 

Scandinaviag

 

n

20

7

7

   

Rate

199.9 (149.0–268.2)

43.8 (21.2–90.6)

24.6 (14.9–40.4)

 

W Europeh

 

n

31

8

8

   

Rate

245.0 (203.3–295.3)

160.8 (112.3–230.4)

46.9 (28.6–76.7)

 

E Europei

 

n

11

6

6

   

Rate

255.4 (178.3–365.9)

89.4 (44.4–180.2)

30.2 (13.2–68.9)

 

Japan

 

n

14

5

5

   

Rate

151.0 (115.5–197.6)

94.5 (69.1–129.3)

69.2 (43.3–110.6)

 

Chinaj

 

n

38

14

14

   

Rate

315.6 (291.6–341.5)

156.5 (117.5–208.4)

106.5 (87.4–129.7)

 

Other Asiak

 

n

7

3

3

   

Rate

67.6 (26.1–174.8)

79.5 (36.7–172.2)

39.0 (11.2–135.7)

 

Betweene

 

PB

<0.001

NS

<0.05

  

1930–60

n

36

11

11

   

Rate

120.7 (103.7–140.6)

59.6 (45.8–77.6)

8.2 (6.5–10.4)

  

1961–70

n

26

8

8

   

Rate

203.4 (161.2–256.8)

110.7 (68.4–179.1)

33.8 (19.4–58.7)

  

1971–80

n

46

18

18

   

Rate

285.5 (246.1–331.2)

143.5 (101.9–202.2)

55.7 (42.1–73.6)

  

1981–90

n

81

40

40

   

Rate

340.6 (312.8–370.9)

125.3 (105.4–148.9)

97.9 (84.7–113.2)

  

1991–99

n

31

4

4

   

Rate

326.5 (283.8–375.5)

165.6 (111.5–246.1)

126.7 (108.4–148.0)

  

Betweene

PB

<0.001

<0.01

<0.001

  1. a n = number of estimates combined, Rate = random-effects meta-analysis lung cancer mortality rate per 100,000 per year for age 70–74 years (95% CI), H = heterogeneity per degree of freedom, PH = probability value for heterogeneity expressed as p < 0.001, p < 0.01, p < 0.05, p < 0.1 or NS (p ≥ 0.1), PB = probability value for heterogeneity between levels (see Methods) similarly expressed.
  2. b All or nearest available, must include at least squamous cell carcinoma and adenocarcinoma.
  3. c Squamous cell carcinoma or nearest available, but not including adenocarcinoma.
  4. d Adenocarcinoma or nearest available, but not including squamous cell carcinoma.
  5. e Heterogeneity between levels of factor considered.
  6. f Including Argentina, Brazil, Cuba, Uruguay.
  7. g Including Denmark, Finland, Iceland, Norway, Sweden.
  8. h Including Austria, Belgium, France, Germany, Greece, Italy, Netherlands, Spain, Switzerland.
  9. i Including Czechoslovakia, Hungary, Poland.
  10. j Including China, Hong Kong.
  11. k Including Singapore, South Korea, Thailand.