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Figure 2 | BMC Cancer

Figure 2

From: TP53p.R337H is a conditional cancer-predisposing mutation: further evidence from a homozygous patient

Figure 2

Whole body magnetic resonance imaging of the TP53 p.R337H homozygous patient. (a) Coronal plane T1 Turbo Spin Echo (TSE) weighted image, (b) coronal plane Turbo Short TI Inversion Recovery (STIR) image and (c) coronal plane image recorded after diffusion-weighted imaging (DWI) on the axial plane with further maximum intensity projection (MIP) reconstruction. Imaging: Brain and whole body magnetic resonance imaging studies were conducted using a 1.5 Philips Achieva (Philips Healthcare, Latham, NY, USA) series scanner following the protocols described [25, 26], with modifications. The diffusion-weighted imaging with body background suppression protocol using a free-breathing technique, as described [27], was applied. In brief, T1 Turbo Spin Echo (T1 TSE) weighted images (T1) and Short TI Inversion. Recovery (STIR) were performed on the coronal plane, and diffusion-weighted imaging (DWI) was performed on the axial plane with further maximum intensity projection (MIP) reconstruction on the coronal plane. We used the body coil and asked for the breath to be held for the thorax and abdomen image acquisitions. Restricted diffusion was observed in the area corresponding to the bone marrow of the lower limbs but followed the expected pattern for age, as described previously [28].

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