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Table 1 T-UCRs altered by ATRA

From: Expressional alterations in functional ultra-conserved non-coding rnas in response to all-transretinoic acid - induced differentiation in neuroblastoma cells

T-UCR name

SK-N-BE (n=2)

LAN-5 (n=2)

SH-SY5Y (n=2)

Type

Orientation with host gene

Host gene

UCR_host correlation

Previously reported data

p-value

uc.324

5.57

2.68

9.86

Exon

anti-sense

MPPED2

  

0.0019

uc.127a

2.02

2.12

1.57

Intergenic

0

0

  

0.0026

uc.75

1.86

2.66

1.77

Exon

anti-sense

ZEB2

  

0.0030

uc.345a

2.02

2.37

1.92

Intron

anti-sense

HOXC4

  

0.0066

uc.409

2.29

2.45

2.33

Intergenic

0

0

 

FRA<2MB (Calin et al., 2007)

0.0107

uc.109

3.58

2.16

3.52

Intron

anti-sense

LOC375295

 

HOX cluster (Calin et al., 2007)

0.0123

uc.113a

2.46

2.48

1.33

Intergenic

0

0

  

0.0134

uc.465a

2.62

1.89

1.63

Intron

anti-sense

POLA1

  

0.0154

uc.344

1.41

2.86

3.38

Intron

sense

HOXC4

Sig. correlated

FRA<2MB (Calin et al., 2007)

0.0156

uc.359a

5.08

2.35

1.33

Exon

sense

NOVA1

Sig. correlated

 

0.0194

uc.198a

1.31

2.25

2.76

Intergenic

0

0

  

0.0204

uc.206

1.14

2.01

2.24

Intergenic

0

0

  

0.0245

uc.217

1.25

2.39

2.44

Exon

sense

VSTM2A

Sig. correlated

 

0.0256

uc.451

1.15

3.01

4.67

Intron

anti-sense

TSHZ3

  

0.0297

uc.341a

1.28

4.54

1.92

Exon

anti-sense

HOXC10

 

FRA<2MB (Calin et al., 2007)

0.0303

uc.396

1.11

3.77

1.75

Intergenic

0

0

 

Down-regulated in HCC (Calin et al., 2007)

0.0346

uc.481a

0.38

0.41

0.33

Exon

anti-sense

STAG2

  

0.0005

uc.195a

0.50

0.38

0.21

Intron

sense

C6orf167

No data available

 

0.0013

uc.49a

0.48

0.66

0.29

Exon

sense

FAM98A

No data available

Inferred role in differentiation for UCR49 (Mestdagh et al., 2010)

0.0082

uc.449

0.42

0.49

0.64

Intron

sense

ZNF536

No data available

 

0.0086

uc.203

0.18

0.47

0.59

Exon

sense

QKI

Sig. correlated

LOH (Calin et al., 2007)

0.0097

uc.48

0.31

0.75

0.31

Exon

anti-sense

PUM2

  

0.0109

uc.419a

0.35

0.78

0.36

Exon

sense

SFRS1

Not Correlated

FRA<2MB, HPV16<2.5MB (Calin et al., 2007)

0.0125

uc.50a

0.35

0.68

0.27

Intron

sense

SFRS7

Sig. correlated

 

0.0131

uc.300a

0.38

0.51

0.79

Intron

anti-sense

PAX2

 

LOH, HOX gene, Up-regulated in CRC (Calin et al., 2007)

0.0135

uc.284

0.81

0.09

0.14

Intergenic

0

0

  

0.0138

uc.48a

0.37

0.59

0.48

Exon

sense

PUM2

No data available

 

0.0160

uc.243

0.59

0.27

0.67

Intron

sense

ZFHX4

Not correlated

AMPLIF (Calin et al., 2007)

0.0176

uc.163

0.59

0.41

0.51

Intergenic

0

0

  

0.0179

uc.388

0.28

0.75

0.47

Intron

sense

TCF12

No data available

Up-regulated in CRC (Calin et al., 2007) Down-regulated in CRC (Sana et al., 2012)

0.0202

uc.97

0.55

0.65

0.28

Intron

sense

HAT1

Not correlated

HOX gene (Calin et al., 2007)

0.0307

uc.82a

0.40

0.37

0.99

Intergenic

0

0

  

0.0499

  1. Table shows the mean fold change across two samples for each cell line following ATRA treatment. 32 T-UCRs showed significantly altered expression following ATRA treatment across all samples (p<0.05).